I would say that the biggest ingredient to make its way to the supplement market has been "Geranium extract AKA http://www.1-3-dimethylamylamine.com/ it is used in nearly all pre workout supps nowdays and has all kinds of effects.

There was some rumours that this isnt from geranium at all but the claim was made so it could be classed as a natural supplement and therefore bypass the FDA regulation process.

Its been known to cause "Stim dick" temporary erectile dysfunction (although you will never see that on a label, only in forums).

I would expect it to be being used by most high level athletes.