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Posted On:
3/03/2009 8:16pm--
Speaking of which, I'm not so pleased with the doctor I went to see about said concussion. She recommended I start taking ibuprofen "to reduce swelling in my neck".
-Browne et al., Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in ratsTraumatic brain injury (TBI) can induce progressive neurodegeneration in association with chronic inflammation. Since chronic treatment with the non-steroidal anti-inflammatory drug (NSAID), ibuprofen, improves functional and histopathologic outcome in a mouse model of Alzheimer's disease (AD), we investigated whether it would also improve long-term outcome following TBI. Anesthetized adult rats were subjected to fluid percussion brain injury. Over the following 4 months the injured animals received ibuprofen per os (formulated in feed) at the approximate doses of 20 mg/kg body wt/day (n = 13), 40 mg/kg body wt/day (n = 13), or control (feed only, n = 12). Sham animals underwent surgery without injury or ibuprofen treatment (n = 9). At 4 months post-injury, a Morris water maze task revealed a profound learning dysfunction in all three injured groups compared to the sham group. Surprisingly, the learning ability of injured animals treated with either chronic ibuprofen regimen was significantly worsened compared to non-treated injured animals. However, there was no difference in the extent of progressive atrophy of the cortex or hippocampus between treated and non-treated injured animals. These data may have important implications for TBI patients who are often prescribed NSAIDs for chronic pain.
Son of a bitch. -
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Posted On:
3/03/2009 8:30pm
Style: Mixed Martial Arts--
I hope that your neurologist wasn't the one suggesting ibuprofen?
Often, following some sort of traumatic injury to the brain anti convulsants such as valproate may be prescribed as a prophylactic measure to ward of epilepsy, which is really the only medication a neuro is likely to prescribe under the circumstances. -
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Posted On:
3/03/2009 8:45pm--
No, I still haven't seen a neurologist (something else I'm pissed off about right now). This is the doctor who said she'd give me the referral to the neurologist (no word yet).
A grab-bag of other stuff that came up in my search...
Modest cooling hasn't been adequately investigated yet, but I've noticed my head feels better when I'm outside in the cold, so I'm going to swap my headphones for an icepack.
Ah, that's nice.
I'm curious as to how things are going to pan out with COX-2 inhibitors and the like, but I'm not about to go out and play amateur pharmacist with this stuff.
Although... Pharmacotherapy for Traumatic Brain Injury: A Review mentions IGF-1 as a possible treatment. Now that's my kind of medicine.
Edit: This study indicating the inefficicacy of cognitive therapy for treating TBI does not surprise me. "Mind over matter" doesn't work that way.Last edited by TheRuss; 3/03/2009 8:52pm at .
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Posted On:
3/03/2009 10:18pm -
is badder than you
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Posted On:
3/03/2009 10:25pm--
To be cynical, that's probably because we aren't far enough along in our understanding of:
-what breaks
-when it breaks
-what will help
-what will harm
As such, we can either adopt the leap-of-conjecture approach of "well, the brain gets inflamed, so let's go with anti-inflammatories", or we can keep whacking rats on the head until theoretical and experimental data strongly correlate. If I sound bitter, it's because I am, not because I have any better ideas.
Speaking of leap-of-conjecture, it pains me to hear the incessant "antioxidants good, free radicals bad" yammering. It's chemistry by people who don't understand chemistry. -
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Posted On:
3/04/2009 1:29pm -
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Posted On:
3/04/2009 5:52pm -
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Posted On:
3/04/2009 7:35pm--
Good question. Unfortunately, I can't give a very good answer to that one. Here's what I can say...
No, I never did Stronglifts 5x5.
In high school, I had no understanding of anything theoretical, and the only goal I really had was to put up more reps than the rest of my football team on bench press at "the next testing" (which never came). The weights and barbell that came with the death trap of a bench I was using only went up to maybe 130lbs if that, so I wound up just putting that up for one set of as many reps as I could. I vaguely recall being able to put it up for a lot of reps in the end. Oddly enough, aside from getting my fingers pinched by the barbell sleeve and bench rests, I think that was the longest continuous run of resistance training I'd ever managed.
Between HS and university, I went to a gym with a bunch of machines. My strategy was to go there about three times a week and do a set on every machine there in sequence, usually three times around. I only did that for a few weeks. Don't remember if I got any results from it.
At university, the strength and conditioning coach would usually give us a weight training program for the off-season. Block periodization kind of stuff - anatomical adaptation, hypertrophy 1, max strength 1, active rest, hypertrophy 2, max strength 2, conversion to strength, and back to football. I usually made it about the middle of hypertrophy before I'd get hurt, sick, or busy with school and gave up.
For a few months after New Year, the team had mandatory twice-weekly "morning runs" - heavy focus on conditioning, with a bit of speed/power and core strength work. I'm quite sure that getting a maximum of three or four hours of sleep per night twice a week for three months offset any benefit I could have gotten out of them, though.
I signed up at a local sports-training place for a summer in there somewhere. It was kind of CrossFit-ish, although I think this was before anyone had actually heard of CrossFit. That's about when I started to get interested in the theoretical end of training. Unfortunately, that was also the summer I first went on creatine after already having put on a lot of weight, and between the added mass and the strain from the training, my body basically fell apart. Sprained ankles from tripping on the sidewalk, etc. An astute reader may be starting to notice a trend here...
Actually, two trends. The other one is that I haven't been able to give too many specifics thus far, which is basically because I didn't start logging my training until three years ago, and those logs are kind of spotty. I'll take a look at said logs when I have the energy to do so.
I can tell you in advance, though... I don't think I've ever managed to train for more than two months without a serious injury (where "serious" is defined as having to discontinue one of the exercises or miss multiple workouts in a row). Frustration with that trend is one of the reasons that I started this thread.Last edited by TheRuss; 3/04/2009 7:38pm at .
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Posted On:
3/04/2009 8:08pm
Style: Kickboxing, swashbuckling--
All this talk of concussions has me worried now.
Are they still such a big deal if it's not a 'serious' concussion? I.E. getting your bell rung/dizzied but not knocked out? Should you still take time off after that? Maybe only a few days, as opposed to a few weeks? Is it alright to continue working out, going to class and all that, as long as you're not doing any hard sparring? Does the severity of the concussion make a huge difference? For example, I got knocked out once playing a game of pickup football, but I was awake again just after hitting the ground. Another time, I got into a fairly serious motorcycle crash, hit a tree at some 40-50mph. I was knocked out for at least 30 seconds, and afterwards while I was being driven to the hospital I remember being extremely sleepy, having my vision blurred, colors screwed up, my tongue tasting fuzzy, ect. How do the two compare? Obviously the crash was worse, but is it by a little or a lot?



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Posted On:
3/03/2009 7:15pm
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