7/01/2009 1:31am, #211
I am taking Baclofen because I have a neuromuscular disorder which causes spasticity (as the area to the left of this post indicates).
7/05/2009 11:44pm, #212
series of letters between Lou Gehrig and his doctor between his diagnosis and death.
It's painful to see how little we've advanced as a society in terms of medical quackery. Supplementation with vitamins and amino acids, miracle cures peddled by "reliable" sources, and... this cracked me up.
There is a new fad in New York, which folders I am sending you under separate cover. This fad is the drinking of raw vegetable juices and two new shops have been opened in New York and all the belles who are on the verge of falling apart are just flocking these places in their idle moments.
Eleanor, yesterday, was virtually dragged into one of these joints and had hardly seated herself when one of these carrot top, anemic dames walked up and attempted to sell her wheat germ pills with the statement that "these are what cured Lou Gehrig."
7/07/2009 8:13pm, #213
7/07/2009 8:19pm, #214
I'm not sure benadryl is going to help you if other anti-allergy, anti-histamine, anti-inflammatories haven't helped....
Best of luck though... Here's hoping.
I assume you've tried Ibuprofin already since it's one of the better anti-inflammatories....
7/07/2009 8:40pm, #215
Ibuprofen + concussions = bad news. Found that one out the hard way.
I've got high hopes for the vasoconstriction end of things with Benadryl, though. It sounds like most of the non-drowsy antihistamines are designed not to penetrate the blood-brain barrier, which is useless to me.
7/07/2009 10:16pm, #216
It does prevent vasoconstriction...
7/07/2009 10:26pm, #217
7/07/2009 10:32pm, #218
Pharmacodynamics: Diphenhydramine is a first generation antihistamine and is a H 1 receptor antagonist. Antagonism is achieved through blocking the effect of histamine more than blocking its production or release. Diphenhydramine inhibits most responses of smooth muscle to histamine and the vasoconstrictor effects of histamine. The antagonism may also produce anticholinergic effects, antiemetic effects, and significant sedative side effects.
Emphasis is mine. Looks like it prevents vascoconstriction....
7/07/2009 10:39pm, #219
Benadryl and related compounds completely annul the vasodilator effect of the minimal doses of histamine which produce maximal vasodilatation.
Edit: Check that.
In contrast to the systemic circulation, in the pulmonary circulation, histamine generally elicits vasoconstriction mediated by H1-receptors and vasodilatation by H2-receptors.
7/07/2009 10:49pm, #220
Hmmm, what ramifications will that have for the brain? I BARELY understand what I'm reading here, you're background is a lot stronger than mine here.