How Can Ki Produce Biochemical Effects?
Machi measured the intensity of infrared radiation from a Qigong healer and estimated it to be ∼10 µW(12). This leads us to a serious question as to how such a minute amount of energy could trigger tangible biochemical reactions. A possibility may be found in the mechanism of the ‘cascade reactions’ of cellular signal transduction. We have already demonstrated that Ki decreased the expression of messenger RNA for c-myc and increased that for regucalcin in cultured human carcinoma cells, HepG2. Using western blot technique, it was proven that the amount of regucalcin protein indeed increased (3). The mechanism may be explained like this: If a small amount of enzyme A is expressed by Ki, then its product B accumulates. If B happened to be another enzyme or an activator of an enzyme C, then its product D would accumulate to hundreds of thousands times greater than the amount of A. In cells, many signal transduction mechanisms, consisting of cytokines, receptors, activators and genes, form intimately linked networks to regulate biochemical and genetic reactions. Therefore, a minute change of a component could quickly be amplified millions of times to produce measurable changes in the system.
Although we do not know how infrared radiation can trigger such a change in cellular systems, we could speculate on a possibility. Most bending and stretching vibrations of many chemical bonds can be identified by absorption spectroscopy in a mid-infrared range (2.5–50 µm) (Table 1). The overtones (1st harmonics with 1/2 wavelength and 2nd harmonics with 1/3 wavelength) of these vibrations fall in the near-infrared range. Therefore, it is possible that a particular frequency of Ki may modulate the vibration of a chemical bond of an enzyme in such a way that it affects its enzymatic activity. If this happens, the microscopic change may be multiplied by the cascading nature of the signal transduction mechanism and result in an observable macroscopic change.