Medications and Injury (FLONASE)

[Dio]

I heard from a friend of mine that using FLONASE (nasally-administered synthetic corticosteroid for allergy sufferers) reduces the body's ability to heal itself effectively, does anyone have any advice to support or disprove this?

[Mr. Mantis]

I heard from a friend of mine that using FLONASE (nasally-administered synthetic corticosteroid for allergy sufferers) reduces the body's ability to heal itself effectively, does anyone have any advice to support or disprove this?

corticosteriods generally slow the healing process, yes.

[Ronin]

I have used flonase for a few years, I heal like wolverine.

[Judah Maccabee]

Quick google search reveals the following:

http://www.healthtouch.com/bin/EContent_HT/drugShowLfts.asp?fname=usp0374.htm&title=Flonase+%2C+Fluticasone&cid=HT


Children—Corticosteroids taken by mouth or injection have been shown to slow or stop growth in children and cause reduced adrenal gland function. If corticosteroids are medically necessary to control nasal problems in a child, nasal corticosteroids are generally considered to be safer than corticosteroids taken by mouth or injection. Prolonged or high-dose use of nasal corticosteroids may potentially affect growth; although, most nasal corticosteroids have not been shown to affect growth. Also, use of most nasal corticosteroids may allow some children to stop using or decrease the amount of corticosteroids taken by mouth or injection.

Before this medicine is given to a child, you and your child's doctor should talk about the good this medicine will do as well as the risks of using it. Follow the doctor's directions very carefully to lessen the chance of unwanted effects.


http://64.233.167.104/search?q=cache:oMA7R5C2a-kJ:www.medscape.com/viewarticle/423228_print+Corticosteroids+healing+wounds&hl=en


Robert H. Demling, MD; Leslie DeSanti, RN From Brigham & Women's Hospital, Boston, Massachusetts.
Wounds 13(5):203-208, 2001. © 2001 Health Management Publications, Inc

Abstract and Introduction
Abstract
Exogenous corticosteroid administration is known to impair wound healing. Patients with severe burns or wounds who require corticosteroids for management of an underlying disease have an increased rate of catabolism and decreased rate of healing. Anabolic steroids have been reported to restore anabolism and wound healing. Our objective was to determine if the oral anabolic steroid oxandrolone could increase the rate of wound healing by decreasing the rate of catabolism in corticosteroid-dependent patients with burns and partial-thickness wounds. Twenty-two corticosteroid-dependent patients with major burns (12) or skin slough disorders (10) were studied. All burn patients required a skin graft, and reepithelialization of the donor site was used as a marker of healing. The skin slough disorders were all partial thickness, and reepithelialization of the wounds was the marker for healing. The burns and skin slough disorders were divided into a standard care group and standard care plus oxandrolone (20mg/day) group. The disorders requiring corticosteroids were collagen vascular disease (12), organ transplant (4), and asthma, or other respiratory diseases (6). Twenty patients survived. The two deaths were in patients with progressive graft versus host disease. No complications relative to the control of the underlying disease were noted with use of the anabolic steroid. We found that the time to healing of skin donor sites in the standard care group was 20 ± 4 days compared to 13 ± 3 days in the oxandrolone-treatment burn group, a significant difference (p < 0.05). We found that the time to reepithelialization in the skin slough disorders with standard care was 25 ± 6 days compared to 17 ± 4 days with the addition of oxandrolone, also a significant difference (p < 0.05). Weight loss was 50-percent less with the addition of oxandrolone compared to standard care, also a significant difference (p < 0.05). We can conclude that providing an anabolic steroid to a corticosteroid-dependent burn or wound patient eliminates the impaired wound healing.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4004002&dopt=Abstract


Corticosteroids in corneal endothelial wound healing.

Singh G.

Corticosteroids have inhibitory effects on corneal endothelial wound healing in organ-culture conditions. Low concentrations of methylprednisolone added to the culture medium inhibited the healing attempt and induced intracellular degenerative vacuoles and diffuse cell disintegration. Higher concentrations were highly toxic to the cell morphology and physiology and caused pronounced endothelial cell damage. These observations are compared with the normal healing of endothelial wounds in organ-culture conditions. Cell proliferation and amitotic and mitotic cell divisions repaired the endothelial layer in normal corneas.

Looks like there's definitely an inhibiting effect to some degree under several circumstances.

[Mr. Mantis]

I think it's all a matter of dosage.

[Yrkoon9]

To combat the effects, I use Human Growth Hormone injected directly into my stomach.

[Mr. Mantis]

To combat the effects, I use Human Growth Hormone injected directly into my stomach.

into the "stomach" or into the viscera or intramuscularly?

[Michael Quach]

True enough, systemic corticosteroids are known to impair wound healing. Flonase, however, is a topical steroid, and the systemic absorption should be almost nonexistent, and so it should NOT impair wound healing. Please refer to the passage below, taken from a fairly recent medical journal.


Taken from "Pharmacologic management of allergic rhinitis.
Rachelefsky GS - J Allergy Clin Immunol - 01-FEB-1998; 101(2 Pt 2): S367-9
From NIH/NLM MEDLINE "


Topical corticosteroids are considered the "gold standard" of therapy for the symptoms of allergic rhinitis. [5] They are effective in reducing nasal blockage, itching, sneezing, and rhinorrhea in allergic and nonallergic noninfectious rhinitis. They are most effective when started several days before an allergen or irritant exposure, and should therefore be used on a regular rather than an "as needed" basis. The clear advantage of topical delivery is that agents act locally rather than systemically. This local action virtually eliminates any systemic side effects. [6] Local side effects, although uncommon, include nasal irritation and bleeding, which are often due to the drug-delivery device or to the local effect of the spray, rather than being a side effect of the drug per se.


Your friendly neighborhood physician,
Michael Quach, MD
Pediatric Neurologist

[Ronin]

Flonase worked very well BTW, no side effects at all.
Well, besides that whole increase of penis size thing, but nothing a few wraps around the leg couldn't take care of.

[Dio]

Thanks all, for both informing and entertaining me :)

[Equipoise]

Of course you pansies could just deal with pollen and other allergens like the rest of us without relying on nose crack. :icon_evil

[Dr. Fagbot Q. MacGillicuddy, PhD]

i got put on flonase a few years back... after a week or two, i spontaneously generated a nosebleed that scared me so much i called a paramedic buddy of mine. hit a serious gusher - my apartment looked like a crime scene, even more so than usual.

best part was when blood started coagulating at the back of my throat... i stood up to run to the sink at one point, because blood was getting all over everything, and coughed something up... when i went back to check i found a dark-red blood clot the size and shape of a large hamburger quivering on my kitchen counter. it was awesome.

[PeedeeShaolin]

i got put on flonase a few years back... after a week or two, i spontaneously generated a nosebleed that scared me so much i called a paramedic buddy of mine. hit a serious gusher - my apartment looked like a crime scene, even more so than usual.

best part was when blood started coagulating at the back of my throat... i stood up to run to the sink at one point, because blood was getting all over everything, and coughed something up... when i went back to check i found a dark-red blood clot the size and shape of a large hamburger quivering on my kitchen counter. it was awesome.

The safety and wonder of modern medicine.